The central composite design was used to develop the controlled release buccoadhesive tablets containing metoprolol tartrate as drug candidate. Carbopol 934P and hydroxy propyl cellulose (HPC) were taken as formulation factors (independent variables). Bioadhesive strength, drug release after 8 hours, T50% and release exponent (n) were taken as responses (dependent variables). The polymers had 50% significant effect on bioadhesive strength and in vitro drug release. It was found that carbopol gives higher bioadhesive strength than HPC. Comparatively HPC controls the drug release greater than carbopol. The optimized formulation follows non-Fickian release mechanism. The FT-IR and DTA studies indicate no physico-chemical interaction. Stability studies revealed that optimized formulation was stable. The predicted values of drug release at 8 hrs, bioadhesive strength, T50% release exponent, n are 64.26%, 44.84 gm, 6.10 50%, hrs, 0.658 and actual values are 60.45%, 43.52 gm, 6.46 hrs, and 0.673 respectively.
Keywords: Metoprolol tartrate, Central composite design, Buccoadhesive, Hydroxy propyl cellulose, Carbopol 934, DTA