Nebivolol a third-generation cardio selective β1-blocker that is approved for the treatment of hypertension. Nebivolol undergoes extensive metabolism in the liver after its oral administration and resulting in to a very poor (approximately 10-12%) bioavailability. Oral administration of nebivolol can also cause gastrointestinal disturbance and abdominal or stomach pain etc. In order to improve the bioavailability, efficacy and to minimize the side effects associated with oral administration, mucoadhesive buccal films of nebivolol using hydroxy propyl methyl cellulose and methyl cellulose were prepared by solvent casting technique. The films of nebivolol using hydroxy propyl methyl cellulose and methyl cellulose were smooth, elegant and uniform in thickness and weight. Among the two polymers used hydroxyl propyl methyl cellulose showed an increased in-vitro residence time due to mucoadhesion nature of the hydroxyl propyl methyl cellulose. Drug content uniformity study showed uniform dispersion of the drug throughout the film in the range of 96.208±1.0705 to th 98.887±0.2558 %. In- vitro drug release study showed that more than 90% of drug was released at the end of 8 hr. The release profile of all the formulations was subjected to various kinetic equations and the results suggested that the drug was released by diffusion mechanism following super case-II transport.
Keywords: Nebivolol, Buccal films, Mucoadhesion, In vitro drug release and Diffusion.