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Published on:21 March, 2012
RGUHS Journal of Pharmaceutical Sciences, 2012; 2(1):55-59
Research Article | doi:10.5530/rjps.2012.1.7

Phytochemical investigation of root extract of the plant Carissa spinarum


Karunakar Hegde1, D. Satyanarayana2, Arun B. Joshi3
1 Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Post- Parangepete, Mangalore- 574 143, Karnataka, India
2Department of Pharmachemistry, N G S M Institute of Pharmaceutical Sciences, Mangalore- 574 160, Karnataka, India
3Department of Pharmacognosy, Goa College of Pharmacy, Panaji- 403 001, Goa, India


From the petroleum ether extract of the roots of Carissa spinarum Linn. (Apocynaceae), six compounds namely stigmasterol, ursolic acid, lupeol, campesterol, 17-hydroxy-11-oxo-nor-β-amyrone and urs-12-ene-3β, 22β-diol- 17-carboxylic acid have been isolated by column chromatography. Their structures were characterized by m.p., IR, 1HNMR, 13CNMR and mass spectral data. However, the compounds stigmasterol, campesterol, 17-hydroxy- 11-oxo-nor-β-amyrone and urs-12-ene-3β, 22β-diol-17-carboxylic acid were reported for the fi rst time from the root of this plant. Keywords: Carissa spinarum, Root extract, Sterol, Triterpenoids