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Published on:21 March, 2012
RGUHS Journal of Pharmaceutical Sciences, 2012; 2(1):60-66
Research Article | doi:10.5530/rjps.2012.1.8

Synthesis and antimicrobial activity of 4-hydroxy-1-methyl/phenyl-3- (substituted anilinoacetyl) quinolin-2(1H)-one

Authors:

Girish Bolakatti1, Manjunatha S. Katagi*1, S.N. Mamledesai2, Sujatha. M.L.3, Prakash Dabadi1, Narayana Miskin.1

1Bapuji Pharmacy College, Davangere 577 004, Karnataka, India
2P.E.S’s College of Pharmacy education and Research, Ponda 403 401, Goa, India
3Bapuji Institute of Engineering and Technology, Davangere 577 004, Karnataka, India

Abstract:

A series of new 2-quinolone derivatives were synthesized, purifi ed and characterized on the basis of IR, 1H NMR, 13C NMR and Mass spectral studies. Same compounds were evaluated for antimicrobial activity against Staphylococcus aureus, Bacillus substilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Asparagillus niger. Among eighteen synthesized novel compounds, in which five compounds (3a, 3b, 3d, 4a, 4c) shows promising antibacterial activity as compared to Ciprofl oxacin (100 μg/ml), however most of them (3a, 3b, 3d, 3e, 4a, 4b, 4d, 4e) showed potent antifungal activity as compared to Fluconazole (100 μg/ml).

Key words: Mass spectral, 2-quinolone, antibacterial and antifungal