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Published on:12th July, 2012
RGUHS Journal of Pharmaceutical Sciences, 2012; 2(2):78
Research Article | doi:10.5530/rjps.2012.2.11

Antipyretic activity of Vitex negundo Linn Leaves extracts


Narayan Miskin1, K.P. Manjunath2, Anant Bhandarkar2, Girish Bolakatti1, Manjunatha S. Katagi1
1 Bapuji Pharmacy College, S.S. Layout, Davangere-577004, Karnataka, India
2 K.L.E.Society’s college of Pharmacy, Vidyanagar, Hubli - 580031, Karnataka, India


The present study intended to investigate the antipyretic activity of leaf extracts of Vitex negundo linn Plant by using yeast induced pyrexia model in Wistar Albino rats. Acute toxicity study and phytochemical analysis was carried out using well established protocols and methods. The phytochemical analysis of leaves revealed the presence of steroids, triterpenoids, alkaloids, flavonoids, tannins and iridiod glycosides. The data obtained indicate that the Petroleum ether and Methanolic extracts of a leaves of plant Vitex negundo linn, at dose of 300 mg/kg body weight per oral route (P.O) showed the significant reduction in yeast provoked elevated temperature. The antipyretic effects of the extracts were compared with standard drug paracetamol.

Keywords: Antipyretic, Paracetamol, Vitex negundo linn, Yeast.