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Published on:12th July, 2012
RGUHS Journal of Pharmaceutical Sciences, 2012; 2(2):62
Research Article | doi:10.5530/rjps.2012.2.9

Hepatoprotective activity of Methanolic extract of Vigna mungo (Linn.) Hepper in Ethanol-induced Hepatotoxicity in Rats

Authors:

M. Nitin1, S. Ifthekar2*, M. Mumtaz3
Department of Pharmacology, H.K.E Society’s MTR Institute of Pharmaceutical Sciences, Sedam road, Gulbarga – 585105, Karnataka, India

Abstract:

Acute administration of ethanol causes liver damage, the present study was undertaken to investigate the hepatoprotective activity of methanolic extract of seeds of Vigna mungo (Linn) Hepper (MEVM) against ethanol-induced hepatic damage in adult albino rats of either sex. The hepatoprotective effect was evaluated on the basis of liver function parameters such as increased (liver weight and volume), elevated serum enzyme levels (glutathione pyruvate transaminase, oxaloacetate transaminase, alkaline phosphatase and total bilirubin) and increased (thiopentone induced sleeping time). The MEVM treated rats produced statistically significant protection. The results were also supported by histological studies on liver cells.

Keywords: Ethanol toxicity, Hepatoprotective activity, Methanolic extract, Vigna mungo.