Purpose: Simple, accurate, precise and economical spectroscopic method for determination of Etodolac in pure and its tablet dosage form by first order derivative method has been developed for the routine analysis. Methodology: Spectroscopic method development for the estimation of Etodolac by first order derivative method was carried out using ethanol as solvent and Shimadzu 1800 Spectronic UV Visible Spectrophotometer. Findings: The absorbance maximum in first derivative spectrum was measured at 273 nm and selected as analytical wavelength. Beer’s law was obeyed in the concentration range of 10-50 μg/ml. The recovery studies ascertained the accuracy of the proposed method and the results were validated as per ICH guidelines. The results were found satisfactory and reproducible. Research application: The method was applied successfully for the estimation of Etodolac in pure drug and tablet dosage form. Industrial application: The method can be applied for routine analysis. Research Value: The newly developed method is a good alternative for HPLC methods and better than zero orders UV methods. Conclusion: The method is simple, rapid, accurate, precise and economic method which can be used without the interference of impurities for the determination of Etodolac in solid dosage forms.
Key words: Etodolac, First derivative method, Spectrophotometric method, UV Estimation,UV determination, Estimation, Tablet assay.
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