Objective: Diurnal variation in gentamicin nephrotoxicity has been previously demonstrated. This study investigated the effect of diurnal variation on gentamicin nephrotoxicity with concurrent artesunate administration in wistar rats. Methodology: Gentamicin (120 mgkg-1) was co-administered with artesunate (100 mgkg-1) at 0000 hrs and 1200 hrs being times of least and greatest gentamicin-nephrotoxicity. Renal biomarkers including creatinine, urea, CAT, SOD, MDA, GPx and electrolytes were determined following seven-day co-administration. Findings: Gentamicin at 1200 hrs produced significant (p<0.05) elevation in serum urea and creatinine in comparison with controls. Animals that received gentamicin at 0000 hrs had significantly lower creatinine and urea levels compared with the 1200 hrs gentamicin group. Artesunate ameliorated gentamicin-nephrotoxicity at both time points with reduction in serum urea and creatinine values. Conclusion: The study showed that artesunate ameliorated gentamicin-induced nephrotoxicity during both periods in rats. Research Value: This research suggests that the concurrent administration of both drugs in bacteremia and parasitemia co-infection may offer beneficial effects of alleviating gentamicin induced nephrotoxicity irrespective of rest or activity time administration.
Key words: Artesunate, Gentamicin, Nephrotoxicity, Diurnal Variation, Chronotoxicity.
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